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Image Search Results
Journal: Oncotarget
Article Title: Compound genetically engineered mouse models of cancer reveal dual targeting of ALK1 and endoglin as a synergistic opportunity to impinge on angiogenic TGF-β signaling
doi: 10.18632/oncotarget.12604
Figure Lengend Snippet: ( A ) qRT-PCR expression levels of ligands BMP10 and GDF5, and receptors ALK1, Endoglin and ALK5 in whole PanNET tumors from RIP1-TAg2 wildtype, and Gdf2 knockout mice at 12 weeks. ( B – D ) Total PanNET tumor volume (B), number of tumors (C) and number of angiogenic islets (D) from RIP1-TAg2 mice at 12 weeks. ( E – J ) Expression correlation of GDF2 and BMP10 against ACVRL1, ENG and an endothelial metagene (CD34, CDH5, PECAM1), (E–I) , and of GDF2 against BMP10 (J) from a human dataset of pancreatic neuroendocrine tumors and metastases ( K – N ) Expression correlation of Gdf2 against Acvrl1 , Eng , an endothelial metagene ( CD34 , CDH5 , PECAM1 ), and Bmp10 (K-N) from a mouse dataset of pancreatic neuroendocrine RIP1-TAg2 islets, tumors and metastases Data are mean ± SEM. * P < 0.05; ** P < 0.01; *** P < 0.001 vs. Wildtype with Student's t-test .
Article Snippet: The following pre-validated primers were obtained from
Techniques: Quantitative RT-PCR, Expressing, Knock-Out